Bioavailable glutathione

Playing a significant role in the pursuit of wellbeing in the meaning of wider vision of health.

Glutathione Thioesters (Bioavailable Glutathione)

Why is it important?

Glutathione is a vital molecule for survival:

- Mother of all antioxidants

- Main detoxifier

- Master of the immune system

The body produces glutathione, but several situations including noncommunicable diseases, poor nutrition, pollution, toxins, medications, stress, trauma, aging, infections and radiation decrease the levels of glutathione in the body.

This makes us subject to:

- Cellular degeneration (oxidative stress and metabolic alterations )

- Infections and cancer

The liver is overstressed and damaged and therefore unable to perform its detoxifying action.


- is the combination of three amino acids: glutamate, cysteine and glycine.

- Glutathione has a strong purifying action due to the presence of sulphur in its molecule. This allows it to capture harmful substances present in the body such as free radicals, toxins, mercury and other heavy metals.

What is its activity?

- Normally, glutathione can not be absorbed by the body because it is not able to cross the cell membrane.

- The peculiarity of the InnBioTec patented molecule, is its ability to cross cell membranes because glutathione is linked to fatty acids.

- When our molecule meets a cell, it behaves like a Trojan horse. It diffuses in phospholipids with fatty acids of the membrane, allowing the glutathione to go through the membrane and reach the inner side of the cell.

- Once inside the cell, the molecule splits into its components, providing two antioxidants and one anti-inflammatory moieties to the body.


When science embraces nature: from the encounter between linseed and yeast the most effective antioxidant available today for cosmetics is born.

Composition and benefits

Renovase® Promotes the renewal of skin cells.

Skin aging

Multifactorial process that combines intrinsic factors (decrease in cellular function genetically programmed during aging) with extrinsic factors (for example, exposure to ultraviolet rays and environmental pollution).

Many scientific studies have shown that in advancing age, a significant reduction in intracellular glutathione (GSH) levels correlated with an increased oxidative stress, occurs in the tissues. The most visible effect is skin aging.

The GSH supplied as such is not able to penetrate into the tissues, due to its hydrophilic nature.

Renovase®, thanks to its lipophilic nature is able to cross cell membranes. Inside the cells, enzymes split the molecule releasing GSH and AGE, which restore the correct antioxidant defenses.

Renovase® has been incorporated into a liposomal structure to ensure the complete skin bioavailability. In this way, therefore, it exerts the most of his activities.

Renovase® enhances and increases the positive effects of both and contains a mixture of three bioactive molecules.

Benefits of Renovase®

Anti Aging Effects

Protects cells from aging caused by the ultraviolet element of the solar radiation:

  • attenuation of expression and aging wrinkles
  • uniformity of skin color
  • a more elastic skin
  • increased hydration and brightness

Whitening Effect

It provides a whitening action on the skin, with a visible reduction of senile skin blemishes. Following the application of the product for at least one week 2 times a day, the effects are immediate:

Scientific evidences

Glutathione (GSH) is the main antioxidant defense of cells and performs fundamental physiological activitie :

Equilibrio ossido-reduttivo cellulare: il residuo di cisteina del glutatione reagisce con i radicali liberi e li inattiva.

Detoxification: GSH at liver level participates in the detoxification mechanisms of xenobiotics. Reacts with endogenous and exogenous toxins (e.g. drugs), producing water soluble conjugates that are excreted with urine.

Modulation of the immunological system: The immune system is very sensitive to levels of GSH and its functionality is compromised in conditions of low levels of glutathione, which are found in conditions of stress, aging and all diseases of degenerative character.

Cellular Regulation: Glutathione participates in the regulation of the pro-oxidant/anti-oxidant balance, upon which many vital functions of the cell depend such as DNA synthesis and repair, protein biosynthesis, and the activation and regulation of enzymes.

Essential fatty acids (AGE, PUFA).

AGEs belong to the category of polyunsaturated fatty acids, as they have more double connections along the carbon chain. Liquids at room temperature are indispensable for the human organism. These acids carry out a wide range of extremely important functions, including the regulation of cholesterol metabolism, the maintenance of cell membranes, moisture and elasticity of the skin, the production of substances with hormonal activity .

Patent Protection


1) Daniel Wright; Mariagioia Zampagni; Elisa Evangelisti; Simona Conti,; Giampiero D’Adamio; Andrea Goti; Claudia Fiorillo; Niccolò Taddei; Cristina Cecchi, Gianfranco Liguri Protective properties of novel S-acyl-glutathione thioesters against ultraviolet-induced oxidative stress Photochemistry and photobiology, 1751-1097, 2012 Aug 30.

2) Mariagioia Zampagni; Daniel Wright; Roberta Cascella; Giampiero D’Adamio; Fiorella Casamenti; Elisa Evangelisti; Francesca Cardona; Andrea Goti; Benedetta Nacmias; Sandro Sorbi; et al. Novel S-acyl glutathione derivatives prevent amyloid oxidative stress and cholinergic dysfunction in Alzheimer disease models. Free Radic. Biol. Med. 52, 1362 (2012).

3) Anna Pensalfini; Cristina Cecchi; Mariagioia Zampagni; Matteo Becatti; Fabio Favilli; Paolo Paoli; Serena Catarzi; Silvia Bagnoli; Benedetta Nacmias; Sandro Sorbi; et al. Protective effect of new S-acylglutathione derivatives against amyloid-induced oxidative stress. Free Radic. Biol. Med. 44, 1624 (2008).

4) A. Pensalfini, C. Cecchi, MG. Zampagni and G. Liguri. Protective effects of GSH-S-acyl derivatives against amyloid-induced oxidative stress. Protein Misfolding and Aggregation in Ageing and Disease, Conferences Jacques-Monod, 11-15 April 2007, Roscoff, France.

5) A. Saragosa. Immortalità: lo scienziato he sfida il tempo con una medusa in testa Il Venerdì di Repubblica, “Scienze”, 56-58, 18 Gennaio 2013

6) Cecchi, C.; Fiorillo, C.; Sorbi, S.; Latorraca, S.; Nacmias, B.; Bagnoli, S.; Nassi, P.; Liguri, G. Oxidative stress and reduced antioxidant defenses in peripheral cells from familial Alzheimer’s patients. Free Radic. Biol. Med. 33:1372–1379; 2002.

7) Schulz, J. B.; Lindenau, J.; Seyfried, J.; Dichgans, J. Glutathione, oxidative stress and neurodegeneration. Eur. J. Biochem. 267:4904–4911; 2000.

8) Taylor, C. R. and A. J. Sober (1996) Sun exposure and skin disease. Annu. Rev.Med. 147, 181-191.

9) Afaq, F. (2011) Natural agents: cellular and molecular mechanisms of photoprotection. Arch. Biochem. Biophys. 508, 144-151.

10) Pence, B. C. and M. F. Naylor (1990) Effects of single-dose ultraviolet radiation on skin superoxide dismutase, catalase, and xanthine oxidase in hairless mice. J. Invest. Dermatol. 95, 213-216.

11) Masaki, H., Y. Okano and H. Sakurai (1998) Differential role of catalase and glutathione peroxidase in cultured human fibroblasts under exposure of H2O2 or ultraviolet B light. Arch. Dermatol. Res. 290, 113-118.

11) Renzing, J., S. Hansen and D. P. Lane (1996) Oxidative stress is involved in the UV activation of p53. J. Cell Sci. 109, 1105-1112.

12) Connor, M. J. and L. A. Wheeler (1987) Depletion of cutaneous glutathione by ultraviolet radiation. Photochem. Photobiol. 46, 239-245.

13) Clydesdale, G. J., G. W. Dandie and H. K. Muller (2001) Ultraviolet light induced injury: immunological and inflammatory effects. Immunol. Cell. Biol. 79, 547-568.

14) Bertling, C. J., F. Lin and A.W. Girotti (1996) Role of hydrogen peroxide in the cytotoxic effects of UVA/B radiation on mammalian cells. Photochem. Photobiol. 64, 137-142.

15) Hanada, K., D. Sawamura, K. Tamai, I. Hashimoto, S. Kobayashi (1997) Photoprotective effect of esterified glutathione against ultraviolet B-induced sunburn cell formation in the hairless mice. J. Invest. Dermatol. 108, 727-730.

16) Hayes, J. D. and L. I. McLellan (1999) Glutathione and glutathione-dependent enzymes represent a co-ordinately regulated defence against oxidative stress. Free Radic. Res. 31, 273-300.

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